Another thing I get asked about is the use of glucosamine chondrointin for support of joints and cartilage. As we age we wear down the cartilage. When bone is rubbing against bone and we experience pain in the joint, it is called osteoarthritis. As the disc material between joints wears down over time we can develop degenerative joint disease - and again the vertebrae can rub down against nerves causing pain. Some recent research has shown that taking glucomasine/chondroitin pills did not regenerate cartilage in the knee and improve osteoarthritis.
Another major glucosamine trial is negative.
The Glucosamine/chondroitin Arthritis Intervention Trial (GAIT), which followed about 570 patients with osteoarthritis of the knee for two years, has found that none of the treatment groups showed a significant benefit (slowing of the narrowing of the joint space).
Sawitzke AD and others. [The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: A report from the Glucosamine/chondroitin Arthritis Intervention Trial. Arthritis & Rheumatism 58:3183-3191, 2008]
http://www.ncbi.nlm.nih.gov/pubmed/18821708
In 2006, the GAIT researchers reported that glucosamine and chondroitin failed reduce osteoarthritis knee pain more effectively than a placebo and that patients who received a standard arthritis drug did about 17% better than the placebo group. [Clegg DO and others. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. New England Journal of Medicine 354:795-808, 2006] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16495392&query_hl=1&itool=pubmed_docsum
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